Novel forms of T cell costimulatory molecules and

专利名称：Novel forms of T cell costimulatory

molecules and uses therefor

发明人：Arlene H. Sharpe,Francescopaolo

Borriello,Gordon J. Freeman,Lee M. Nadler

申请号：US09962969申请日：20010924

公开号：US20030045703A1公开日：20030306

摘要：Novel structural forms of T cell costimulatory molecules are described. Thesestructural forms comprise a novel structural domain or have a structural domain deletedor added. The structural forms correspond to naturally-occurring alternatively splicedforms of T cell costimulatory molecules or variants thereof which can be produced bystandard recombinant DNA techniques. In one embodiment, the T cell costimulatorymolecule of the invention contains a novel cytoplasmic domain. In another embodiment,the T cell costimulatory molecule of the invention contains a novel signal peptide domainor has an immunoglobulin variable region-like domain deleted. The novel structuralforms of T cell costimulatory molecules can be used to identify agents which stimulatethe expression of alternative forms of costimulatory molecules and to identify

components of the signal transduction pathway which results in costimulation of T cells.

申请人：BRIGHT AND WOMEN'S HOSPITAL

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