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专利名称：6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and thecorresponding dihydroxycarboxylic acidderivatives, salts and esters, and in treatinghypercholesterolemia
发明人：Heiner Jendralla,Gunther Wess,Wilhelm
Bartmann,Gerhard Beck
申请号：US07/680613申请日：19910402公开号：US05166171A公开日：19921124
摘要：6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the correspondingdihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation ofthese compounds, their use as pharmaceuticals, pharmaceutical preparations and novelphenols and thiophenols Compounds of the general formula I ##STR1## and thecorresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in whichX, Y and Z have the meanings given, and pharmacologically tolerated salts thereof withbases and pharmacologically tolerated esters thereof, processes for the preparation ofthese compounds, their use as pharmaceuticals and pharmaceutical preparations aredescribed. Novel phenols and thiophenols of the formula III ##STR3## in which X, Y and Z
have the meanings given, are also described.
申请人：HOECHST AKTIENGESELLSCHAFT
代理机构：Finnegan, Henderson Farabow, Garrett and Dunner
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