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专利名称：NANOPARTICULATE BIOACTIVE AGENTS发明人：KREITZ, MARK, R.,JONG, YONG
S.,MATHIOWITZ, EDITH,ENSCORE, DAVID,J.,BASSETT, MICHAEL J.
申请号：EP038181申请日：20031030公开号：EP1569620A4公开日：20060322
摘要：Bioactive agents may be reproducibly converted into particles having diametersin the range of about 5 to about 2000 nanometers (nm). Conversion is accomplished bydissolving the bioactive agent in a solvent for the bioactive agent, and rapidly altering thepolarity of the solution to make it a non-solvent for the bioactive agent, for example bydiluting the bioactive agent solution with an excess of a liquid that is a non-solvent for thebioactive agent but is miscible with the solvent. Precipitated bioactive agent nanoparticlesare collected by centrifugation, filtration or Iyophilization. The nanoparticles have arelatively narrow size distribution, and the average diameter can be controlled by choiceof solvent and non-solvent. The nanoparticles are typically amorphous. A surfactant maybe added to ensure dispersion of the particles when administered. In the preferredembodiment, the bioactive agent is a drug with low aqueous solubility.
申请人：SPHERICS, INC.
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