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专利名称：Adhesives resistant to skin-penetration
enhancers
发明人：Deepak Hariharan,Roman Bradel,Rama
Chandran,Pravin Kukkala
申请号：US08/918173申请日：19970825公开号：US05916968A公开日：19990629
摘要：A graft copolymer for use as an adhesive for drug delivery patches or dressingsthat is resistant to dissolution in the presence of skin penetration enhancers comprisescopolymerized acrylic and, optionally, vinyl monomers, to form a backbone polymer, towhich are grafted polymeric moieties that do not absorb greater than 3% by weight of askin- penetration enhancer under thermodynamic equilibrium at 25° C. if independentlyintroduced into an excess of the enhancer. Preferably, the grafted polymers are selectedfrom the classes of polybutylene, polysaccharide, poly(ethyleneoxide/propyleneoxide),and polyamide polymers, and specific grafted polymers will depend on the specificenhancers used in a particular drug delivery system.
申请人：NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION
代理人：Jane E. Gennaro,Lydia T. McNally
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